The Transformative Leadership of School Principal Paradigm in Developing Students’ Religious and Social Characters

The objective of this research aims to inestigate the transformativeleadership of school principal paradigm in developing the religious and social character of students at SMA Model Palu, Central Sulawesi. This research uses qualitative proposed by Bogdan dan Taylor. The technique of data analysis uses Miles and Huberman qualitative data analysis. The results indicate that, first, transformativeleadership of school principal paradigm is able to build commitment and cooperativeness in making changes, development, and improvement of the learning quality, management of educational quality administration that produces outstanding students. Second, it is able to develop a religious and social culture in changing the thinking and attitude paradigm of students who are obedience to God, honest, sincere, and have a social character in developing the students’ attitudes on cooperativeness, cooperation, brotherhood, empathy, and tolerance. The development of religious and social personalities is carried out in an integrated manner through curricular and extra-curricular activitie

Cytogenetic diagnosis of Roberts SC phocomelia syndrome: First report from Kashmir

There are several syndromes in which specific mitotic chromosomal abnormalities can be seen, like premature centromere separation, premature (sister) chromatid separation, and somatic aneuploidies. Identifications of such specific cytogenetic findings can be the key factor that leads towards the diagnosis of syndromes like Roberts SC phocomelia. The case presented here as Roberts SC phocomelia syndrome was identified as a child with multiple congenital anomalies and dysmorphic features. Conventional cytogenetic analysis of the case revealed premature sister chromatid separation. The premature centromeric separation was also confirmed by C banding analysis of the child. It is the first and the only case of Roberts SC phocomelia diagnosed from this part of the world. The present case report emphasizes the importance of conventional cytogenetics in the diagnosis of such syndromes

Frequency of acrocentric associations in Bhopal gas tragedy survivors

The frequency and patterns of acrocentric associations were determined in the peripheral blood lymphocyte cultures of fifty healthy subjects surviving after the exposure to Bhopal gas tragedy, 1984. Same number of age, sex and area matched individuals were selected as controls. The exposed and the non-exposed groups comprised of 24 males and 26 females each. The results of the present study revealed that the mean percentage of acrocentric associations in exposed population was 20.44±1.38, which was significantly higher (P<0.0001) as compared to the controls (12.20±0.64). The frequency of large as well as small associated acrocentric chromosomes in the exposed subjects was also found to be significantly higher as compared to the controls. The most frequent type of association was DG (D group-G group) type in the exposed males (P<0.0001) and DD (D group-D group) type in the exposed females (P=0.0016). Moreover, DDG and GGD type of associations were also observed in some of the exposed subjects. Higher frequency of satellite associations revealed by our results may predispose the exposed individuals to non-disjunction of chromosomes that may ultimately lead to genomic instability.Keywords: acrocentric association, Bhopal gas tragedy, genomic instabilit

Frequency and pattern of cytogenetic alterations in primary amenorrhea cases of Kashmir, North India

Background: Primary amenorrhea (PA) is proposed to have multiple etiological factors that include genetic factors, intrauterine malformations, endocrine dysfunction and environmental factors, as revealed by previous studies pertaining to amenorrhea. However, among the various proposed etiologies, genetic factors appear to be highly associated with PA as approximately 40% of PA cases have been found to have genetic causes. Aim of the study: The present study was proposed to establish the frequency and pattern of chromosomal abnormalities in PA cases of Kashmir. Subjects and methods: A total of 108 females within the age group of 14–33 years and having a history of amenorrhea were included in the study. Peripheral blood lymphocyte cultures were set for each subject according to standard protocol and chromosomal analysis was carried out on well spread metaphases by the help of Cytovision software Version 3.9. Results: The results of the present study reveal that the incidence of chromosomal abnormalities in PA cases of this region is almost similar with those of many reports around the world. However, we report two unique chromosomal alterations viz., 46,XX, dup2q(13) and 46,XX, t(2,5)(p11.2;q34) that have not been found elsewhere in the literature. Conclusion: The results of the present study indicate that chromosomal analysis of females with PA, after the exclusion of non-genetic causes, should be essentially considered for the precise diagnosis and the development of more successful treatment. The study being the first of its kind in this part of the world forms the basis for further studies of the PA cases of this region. The precise molecular characterization of the unique breakpoint regions reported in our study can possibly help in the identification of new genes involved in primary amenorrhea